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underlying disease or can arise from a conscious effort to improve an actual or perceived overweight or obese state. Unintentional weight loss Unintentional weight loss occurs in many diseases and conditions, including some very serious diseases such as cancer ,. This results in a loss of both fat and lean mass, leading to a significant reduction in total body weight. In addition to weight loss due to a reduction in fat and lean mass, fluid loss can be triggered by illnesses such as diabetes, certain medications, lack of fluid intake or other factors. Causes of unintentional weight loss Starvation , a state of extreme hunger resulting from lack of essential nutrients over a prolonged period. Cancer , a very common and sometimes fatal cause of unexplained idiopathic weight loss. About one-third of unintentional weight loss cases are secondary to malignancy. Cancers to suspect in patients with unexplained weight loss include