Cholenergic Agonists | ANS PHARMACOLOGY

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Cholinergic agonists are drugs that mimic the action of acetylcholine, a key neurotransmitter in the parasympathetic nervous system. These drugs bind to and activate cholinergic receptors, which are classified into muscarinic and nicotinic receptors. Muscarinic agonists primarily affect smooth muscles, cardiac tissue, and glands, producing effects such as decreased heart rate, increased glandular secretions, and smooth muscle contraction. Nicotinic agonists stimulate skeletal muscle and autonomic ganglia. Cholinergic agonists are used in conditions like glaucoma, myasthenia gravis, and urinary retention. However, they may cause side effects such as bradycardia, hypotension, and excessive salivation due to widespread parasympathetic activation.