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Accutane (Isotretinoin) is probably the most talked about prescription acne treatment today. Accutane has been shown to be the most potent acne treatment on the market, producing almost completely clear skin for the majority of users. Accutane is a more potent form of the Tretinoin found in Retin-A, and effects your skin in much the same way. It works primarily by minimizing the activity of your oil glands, potentially shrinking your glands and pores. As with Vitamin B5, the reduction of oil has a powerful effect in eliminating acne.

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