What Causes Gallbladder Disease

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As many as 25 million Americans are estimated to suffer from gallbladder disease, with more than a half-million having their gallbladders removed each year.

The most common thing that goes wrong with the gallbladder is the development of gallstones. There are two types of gallstones: cholesterol stones and pigment stones. Approximately 80% of stones are cholesterol stones which are caused by too much cholesterol or bilirubin (a component of bile), not enough bile salts, or improper emptying of the gallbladder. The cause of pigment stones is unknown but they tend to form in those with liver disease or blood disorders.

“Roughly 20 percent of the people walking around out there have gallstones. They’re a fairly common occurrence,” said Dr. Richard A. Mackey, a biliary and pancreatic surgeon at St. Joseph Medical Center.

Gallstones can continue to grow over time and eventually cause irritation to the gallbladder itself. Sometimes, the gallstones move into the bile duct causing pain or blockage. Pain, nausea and fever are the most common symptoms. Partial or complete blockage can also cause swelling, infection and the need for emergency surgery.

While the causes of gallbladder disease aren’t entirely clear, poor diet, excess calcium and estrogen seem to be involved.


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