Risk Factors For Developing Gallstones

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Hormone replacement therapy and birth control pills. Estrogens tend to increase the amount of cholesterol in the bile and reduce the contracting movement of the gallbladder.
Some cholesterol lowering drugs. Typically not statins. There is some evidence that treatment with statins might actually lower the risk of forming gallstones, but the jury is out until more research comes in. Certainly not a reason to start a statin.

Female. During the reproductive years, women produce plenty of estrogen. Women suffer gallbladder disease at more than three times the rate as men. As many as 20 percent of women have gallstones by the time they are 60 years old.

Obesity. Obesity, especially abdominal obesity, leads to increased levels of cholesterol in the bile. At higher concentrations the cholesterol will be more prone to precipitate out into gallstones.

Pregnancy. The extra estrogen from pregnancy can, as with HRT or birth control pills, increase the cholesterol in bile and reduce the activity of the gallbladder.

Weight loss, especially rapid weight loss. Lack of fat intake allows the bile a chance to sit in the gallbladder and form stones. This last risk we shall cover in more detail.


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