New study explains how SARS-CoV-2 may seize human cells

Another detailed study by the American Association for the Advancement of Science asserts that the SARS-CoV-2 virus not only targets to enter the human cells but begin to replicate and spread as well. The findings also highlight that the possibilities could potentially serve as targets for new therapies for patients with COVID-19, although validation in cells and animal models is needed.

Scientists know that SARS-CoV-2 binds the ACE2 receptor on the surface of human cells, after which it enters the cell through a process known as endocytosis. Research has suggested that the virus may hijack or interfere with other processes such as cellular housekeeping (autophagy) by targeting other receptors called integrins. However, not much is known about exactly how the virus takes advantage of integrins on the biochemical level.