BB King cd4

In June 2006, King was present at a memorialization of his first radio broadcast at the Three Deuces Building in Greenwood, Mississippi, where an official marker of the Mississippi Blues Trail was erected.

In late October 2006, he recorded a live CD and DVD, B.B. KING LIVE, at his B.B. King Blues Clubs in Nashville and Memphis. The four night production featured his regular B.B. King Blues Band and captured his show as he performs it nightly around the world. It was his first live performance recording in 13 years.

B. B. King also made an appearance at the Crossroads Guitar Festival II, established by Eric Clapton in Chicago Illinois on July 28, 2007. On the DVD, he plays "Paying the Cost to Be the Boss" and "Rock Me Baby" with Robert Cray, Jimmie Vaughan and Hubert Sumlin. In the live broadcast, he offered a toast to the concert's host, Eric Clapton, and philosophized about his age and life. This never made it in its entirety to the subsequently released PBS broadcast or Crossroads II DVD.

In June 2006, a groundbreaking was held for a new B. B. King Museum and Delta Interpretive Center in Indianola, Mississippi. The museum opened on September 13, 2008.

B. B. King was also the final performer at the 25th annual Chicago Blues Festival on June 8, 2008.

In June 2008, B. B. King was inducted into the Hollywood Bowl Hall of Fame alongside Liza Minnelli and Sir James Galway.

In July 2008, Sirius/XM Radio's Bluesville channel was re-named B. B. King's Bluesville.

On December 3, 2008 King, along with John Mayer, was the closing act at the 51st Grammy Nomination Concert, playing "Let the Good Times Roll" by Louis Jordan.